Distribution of U5 antigen on lymphocyte subsets in human and nonhuman primates |
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| Authors: | Sayuri Ikura Keiji Terao Osamu Takenaka Atsuo Noguchi Yuichi Murayama |
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| Institution: | (1) Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, 305 Ibaraki, Japan;(2) Tsukuba Primate Center for Medical Science, The National Institute of Health, Tsukuba, 305 Ibaraki, Japan;(3) Primate Research Institute, Kyoto University, Kanrin, Inuyama, 484 Aichi, Japan |
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| Abstract: | The U5 monoclonal antibody developed by immunizing mice with Japanese monkey lymphocytes could react with lymphocytes of primate
species including Old World monkeys, apes, and human. However, the distributions of U5 antigen on major functional subsets
of lymphocytes were different in primate species. The U5 antigen was mainly distributed on natural killer (NK) cells in human,
but on B cells in Old World monkeys. On the other hand, U5 antigen was detected on both B and NK cells in chimpanzees and
gibbons, indicating that the distribution of U5 antigen on lymphocyte might change from B cells to NK cells during primate
evolution. |
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| Keywords: | U5 antigen B cells NK cells Old World monkeys Apes |
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