|
|||||
|
|
Identification of chemokine receptor CCR4 antagonist |
|
| Authors: | Purandare Ashok V Gao Aiming Wan Honghe Somerville John Burke Christine Seachord Carrie Vaccaro Wayne Wityak John Poss Michael A |
| Affiliation: | Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA. ashok.purandare@bms.com |
| Abstract: | The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |