低强度激光血管照射治疗脑损伤的实验研究

本实验采用ＳＤ大鼠脑损伤模型，设对照组和照射组，采用低能量半导体激光器对大鼠股静脉进行血管外照射，水迷宫试验测定大鼠记忆功能，并测定脑组织和血ＳＯＤ、ＭＤＡ含量。结果发现低强度激光血管照射能促进照射组记忆功能的恢复，使ＳＯＤ活性提高，ＭＤＡ含量降低。这提示低强度激光照射改善了脑损伤后脑组织的缺血缺氧状态，从而减轻了氧自由基反应造成的继发性脑损害

Vascular Low Level Laser Irradiation Therapy in Treatment of Brain Injury

To evaluate the effect and mechanism of Vascular Low Level Laser Irradiation Therapy on brain injury. In this study thirty eight SpragueDawley rats received Feeney's brain impact through a left lateral craniectomy under anesthesia. Control and treatment group are set up. According to the time exposed to laser and irradiating postinjury, the treatment group is divided in four subgourps by design. Semiconductor laser was used with a power of 5mW to irridate straightly Rat's femur venous. The Y Water maze was used to assess cognitive performance. Superoxide dismutase(SOD) activity and the level of metabolic production of free radical MDA in Brain and erythrocyte were measured to determinate the level of free radical. We find Vascular Low Level Laser Irradiation Therapy can improve posttraumatic memory deficits. SOD activity is highter in treatment groups than the control group meanwhile the level of MDA is lower. These findings suggest that Vascular Low Level Laser Irradiation produced a significant reduction in free radical's damage to the brain postinjury.