MPTP-induced suppression of corticofugal influences on neurons of the cat caudate nucleus |
| |
Authors: | S A Talanov N N Oleshko M N Tkachenko V F Sagach |
| |
Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
| |
Abstract: | In acute experiments on cats, we demonstrated that the relative number of neurons of the caudate nucleus responding to stimulation
of the motor cortex with latencies shorter than 8.0 msec significantly decreased, as compared with the control, after destruction
of the nigro-striatal dopaminergic system caused by a series of injections of the neurotoxin MPTP. Within 1.5 months, the
number of these cells gradually recovered. We conclude that in the norm dopamine exerts an inhibitory effect on glutamatergic
cortico-striatal impulsation. We hypothesize that the blockade of transmission through cortico-striatal synaptic connections
under conditions of dopamine deficiency is realized due to the toxic effect of glutamate released in excessive amounts on
the corresponding receptors in the above synapses.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 4, pp. 287–291, July–August, 2006. |
| |
Keywords: | dopamine glutamate Parkinson’ s disease motor cortex caudate nucleus MPTP |
本文献已被 SpringerLink 等数据库收录! |
|