Escherichia coli as a model system to study DNA repair genes of eukaryotic organisms |
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| Authors: | Augusto-Pinto Luiz da Silva Carlos Gustavo Regis Lopes Débora de Oliveira Machado-Silva Alice Machado Carlos Renato |
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| Affiliation: | Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, 30161-970 Belo Horizonte, MG, Brasil. |
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| Abstract: | The bacteria Escherichia coli has been widely employed in studies of eukaryotic DNA repair genes. Several eukaryotic genes have been cloned by functional complementation of mutant lineages of E. coli. We examined the similarities and differences among bacterial and eukaryotic DNA repair systems. Based on these data, we examined tools used for gene cloning and functional studies of DNA repair in eukaryotes, using this bacterial system as a model. |
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