Attractin(mahogany/ATRN)基因的研究进展

Attractin（mahogany/mg）是常染色体隐性基因，在近几十年里受到很大关注。已经发现attractin在黑色素沉着、调节运动行为和基础代谢、中枢神经的形成及功能、协调T细胞与巨噬细胞之间的反应等方面都起着十分重要的作用。ATTRACTIN蛋白可以抑制因多食而引起的肥胖，其在大脑中的表达水平与抑制肥胖症成正相关，这将预示它可能用来干扰哺乳动物的肥胖症，而且鼠类attractin基因位于包涵几个体重和肥胖QTL区域内。本文回顾了mg基因的研究历程，介绍其相关性基因及该基因的定位情况，并详细归纳了关于该基因产物在生理过程中的调节机理。在此基础上，提出了进一步研究的思路。 Abstract:Attractin is an autosomal recessive gene and received great attention within the last few decades.Attractin in different lines has been identified attractin to have multiple roles in regulating physiological process.It affects the balance between agonist and antagonist at receptors on melanocytes,modifies behaviour and basal metabolic rate,intervenes developing the central nervous system and its function,and modulates an interaction between activated T cell and macrophages.The attractin gene encodes a protein that is involved in the suppression of diet-induced obesity,its expression level in the brain has a significant relationship with obesity,the role indicates the therapeutic potential of attractin in the treatment of obesity.Furthermore,the murine attractin locus is located in a region harboring several QTL for body weight and fatness.In this paper,we review the research development of mahogany,introduce the related gene and gene mapping,and summarize its regulating mechanism in the physiological process.Additionally,the further research on the gene is also suggested.

Progress in Attractin(mahogany/ATRN) Gene

Attractin is an autosomal recessive gene and received great attention within the last few decades.Attractin in different lines has been identified attractin to have multiple roles in regulating physiological process.It affects the balance between agonist and antagonist at receptors on melanocytes,modifies behaviour and basal metabolic rate,intervenes developing the central nervous system and its function,and modulates an interaction between activated T cell and macrophages.The attractin gene encodes a protein that is involved in the suppression of diet-induced obesity,its expression level in the brain has a significant relationship with obesity,the role indicates the therapeutic potential of attractin in the treatment of obesity.Furthermore,the murine attractin locus is located in a region harboring several QTL for body weight and fatness.In this paper,we review the research development of mahogany,introduce the related gene and gene mapping,and summarize its regulating mechanism in the physiological process.Additionally,the further research on the gene is also suggested.