OptFlux: an open-source software platform for <Emphasis Type="Italic">in silico</Emphasis> metabolic engineering |
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| Authors: | Isabel Rocha Paulo Maia Pedro Evangelista Paulo Vilaça Simão Soares José P Pinto Jens Nielsen Kiran R Patil Eugénio C Ferreira Miguel Rocha |
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| Institution: | 1.IBB-Institute for Biotechnology and Bioengineering/Centre of Biological Engineering,University of Minho,Braga,Portugal;2.Department of Informatics/CCTC,University of Minho,Braga,Portugal;3.Systems Biology, Dept Chemical and Biological Engineering,Chalmers University of Technology,Gothenburg,Sweden;4.Center for Microbial Biotechnology,Technical University of Denmark,Kgs Lyngby,Denmark |
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| Abstract: | Background Over the last few years a number of methods have been proposed for the phenotype simulation of microorganisms under different
environmental and genetic conditions. These have been used as the basis to support the discovery of successful genetic modifications
of the microbial metabolism to address industrial goals. However, the use of these methods has been restricted to bioinformaticians
or other expert researchers. The main aim of this work is, therefore, to provide a user-friendly computational tool for Metabolic
Engineering applications. |
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