Angiopoietin 1 Promotes Tumor Angiogenesis and Tumor Vessel Plasticity of Human Cervical Cancer in Mice |
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Authors: | Winston S. N. Shim Ming Teh Akanksha Bapna Injune Kim Gou-Young Koh Peter O. P. Mack Ruowen Ge |
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Affiliation: | a Molecular Angiogenesis Laboratory, Department of Biological Sciences, National University of Singapore, Singapore, 119260;b Department of Pathology, National University of Singapore, Singapore, 119074;d Department of Surgery, Singapore General Hospital, Singapore, 169608;c National Creative Research Initiatives Center for Endothelial Cells, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja-Dong, Nam-Gu, Pohang, 790-784, Korea |
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Abstract: | Angiopoietins have been increasingly implicated to play important roles in blood vessel formation, remodeling, maturation, and maintenance. However, their roles in tumor angiogenesis and hence tumor growth and metastasis still remain uncertain. In this work, angiopoietin 1 expression was amplified in human cervical cancer HeLa cells by stable transfection or recombinant human adenovirus-mediated gene transfer. We show that increased angiopoietin 1 expression promoted in vivo growth of human cervical cancers in mice by promoting tumor angiogenesis and inhibiting tumor cell apoptosis. Furthermore, we also show for the first time that overexpression of angiopoietin 1 also leads to increased tumor vessel plasticity with a large number of vessels lacking periendothelial supporting cells. These results indicate that angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. |
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Keywords: | tumor angiogenesis angiopoietin 1 vessel plasticity |
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