Use of Antifungal Combination Therapy: Agents,Order, and Timing |
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Authors: | Melissa D Johnson John R Perfect |
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Institution: | 1.Campbell University College of Pharmacy & Health Sciences,Durham,USA;2.Division of Infectious Diseases & International Health,Duke University Medical Center,Durham,USA |
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Abstract: | Given the substantial morbidity and mortality related to invasive fungal infections, treatment with a combination of antifungal
agents is often considered. A growing body of literature from in vitro studies, animal models, and clinical experience provides
data evaluating this approach. This review describes combination antifungal strategies for the management of cryptococcal
meningitis, invasive candidiasis, invasive aspergillosis, and rare mold infections. The potential effects that sequencing
and timing have on the efficacy of such approaches are discussed, with a focus on recent clinical data in this arena. |
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Keywords: | |
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