The two-mutant problem: clonal interference in evolutionary graph theory |
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Authors: | Chris Paley Sergei Taraskin Stephen Elliott |
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Institution: | (1) Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK; |
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Abstract: | In large asexual populations, clonal interference, whereby different beneficial mutations compete to fix in the population
simultaneously, may be the norm. Results extrapolated from the spread of individual mutations in homogeneous backgrounds are
found to be misleading in such situations: clonal interference severely inhibits the spread of beneficial mutations. In contrast
with results gained in systems with just one mutation striving for fixation at any one time, the spatial structure of the
population is found to be an important factor in determining the fixation probability when there are two beneficial mutations. |
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Keywords: | Clonal interference Spatial population Fixation probability Beneficial mutations |
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