| 表观遗传修饰在学习和记忆中的调节作用 |
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| 引用本文： | 姚志刚,秦川.表观遗传修饰在学习和记忆中的调节作用[J].中国实验动物学报,2011,19(5):441-445. |
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| 作者姓名： | 姚志刚 秦川 |
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| 作者单位： | 北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 |
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| 基金项目： | 卫生公益性行业科研专项，国家重大科技专项 |
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| 摘 要： | 学习和记忆行为是大脑的基本功能,它使得生物个体能够更好地适应环境的变化。揭示学习和记忆的分子生物学机制是现代神经生物学发展的目标之一。经过近40年的研究现已初步证实了突触可塑性在学习和记忆中所起的关键作用。而近年来的研究发现,表观遗传修饰对学习和记忆过程具有重要的调控作用。这一发现将有利于进一步揭示学习和记忆的复杂机制,并将为某些认知障碍性疾病的治疗提供新的思路。
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| 关 键 词： | 突触可塑性 记忆 表观遗传学 |
Epigenetic regulation in learning and memory: a review |
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| YAO Zhi-gang,QIN Chuan.Epigenetic regulation in learning and memory: a review[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(5):441-445. |
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| Authors: | YAO Zhi-gang QIN Chuan |
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| Institution: | YAO Zhi-gang,QIN Chuan(Comparative Medicine Center,Peking Union Medical College(PUMC),and Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences(CAMS),Key Laboratory of Human Disease Comparative Medicine,Ministry of Health,Key Laboratory of Human Disease Animal Models,State Administration of Traditional Chinese Medicine,Beijing 100021,China) |
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| Abstract: | Learning and memory are fundamental functions of the brain allowing individuals to adapt the environmental changes more efficiently.To unravel the molecular and cellular bases of learning and memory is one of the goals of modern neuroscience.Over the past 40 years,the crucial role of synaptic plasticity in learning and memory has been initially confirmed.However,recent studies have found that epigenetic modifications also play important roles in the process of learning and memory regulation.These findings w... |
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| Keywords: | Synaptic plasticity Memory Epigenetics Brain |
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