The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab

Authors:	Hilde Berner Hammer Magne K Fagerhol Tale Norbye Wien Tore K Kvien

Affiliation:	1.Dept of Rheumatology, Diakonhjemmet Hospital, Box 23, 0319 Oslo, Norway;2.Blood Bank and Dept of Immunology, Oslo University Hospital, Ullevål Hospital, Kirkeveien 166, 0450 Oslo, Norway;3.Dept of Internal Medicine, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0372 Oslo, Norway

Abstract:	Introduction Calprotectin (MRP8/MRP14, S100A8/A9) is associated with disease activity in patients with rheumatoid arthritis (RA). Ultrasonography (US) is a reliable method for evaluation of synovitis (B-mode (BM) and power Doppler (PD)). The present objectives were to explore in RA patients the associations between calprotectin and a comprehensive US examination, as well as the responsiveness of calprotectin compared to other inflammatory markers during anti-TNF treatment.

Keywords:	Calprotectin acute phase proteins rheumatoid arthritis ultrasonography anti-TNF treatment
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