Ion concentration dynamics as a mechanism for neuronal bursting |
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Authors: | Ernest Barreto John R Cressman |
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Institution: | (1) Center for Neural Dynamics, Department of Physics & Astronomy, and The Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA |
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Abstract: | We describe a simple conductance-based model neuron that includes intra- and extracellular ion concentration dynamics and
show that this model exhibits periodic bursting. The bursting arises as the fast-spiking behavior of the neuron is modulated
by the slow oscillatory behavior in the ion concentration variables and vice versa. By separating these time scales and studying
the bifurcation structure of the neuron, we catalog several qualitatively different bursting profiles that are strikingly
similar to those seen in experimental preparations. Our work suggests that ion concentration dynamics may play an important
role in modulating neuronal excitability in real biological systems. |
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Keywords: | Neuron Potassium Sodium Ion concentration Burst Seizure Epilepsy |
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