Chemical genetics: tailoring tools for cell biology |
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Authors: | Mayer Thomas U |
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Institution: | Max Planck Institute of Biochemistry, Department of Cell Biology, Am Klopfersitz 18a, D-82152 Martinsried, Germany. mayer@biochem.mpg.de |
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Abstract: | Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future. |
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