Enhancement by LPS of B-cell function in genetically deficient mice. |
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Authors: | P A Campbell P D Kind |
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Affiliation: | 1. Section of Allergy and Clinical Immunology, National Jewish Hospital and Research Center, Denver, Colorado 80206, USA;2. Department of Microbiology, The George Washington University School of Medicine, Washington, D.C. 20037 USA |
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Abstract: | CBA/N mice are apparently deficient in mature B cells, but not in immature B cells. Experiments reported here were designed to test the ability of the adjuvant and B-cell mitogen, bacterial lipopolysaccharide (LPS), to induce B-cell function in CBA/N mice. CBA/N spleen cells, which respond poorly to erythrocyte antigens in vitro, developed high numbers of hemolytic antibody-forming cells when cultured with LPS. When injected along with erythrocyte antigens, LPS enhanced in vivo immune responses, as shown by increases in direct and indirect hemolytic antibody-forming cells. These data demonstrate that both in vivo and in vitro, in the presence of LPS, CBA/N B cells can become antibody-forming cells. |
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