药用植物基因组及EST研究

以生物信息学数据库GenBank的生物信息为基础 ,对包括《中国药典》2 0 0 0年版一部、《新编中药志》第 1～ 3卷、《中国大百科全书》(中国传统医学分册 )、中国医学科学院药物研究所编写的《中草药现代研究》及《天然药物化学》第三版中所涉及的 2 30 0多种药用植物的基因组、蛋白质及表达序列标签 (EST)的注册情况进行了初步统计 ,就相关进展进行了综述。到 2 0 0 3年 9月底截止的数据分析表明 ,66%的药用植物没有核酸序列报道 ,77%的药用植物没有蛋白质序列注册。进行药用植物基因组研究的植物与国家十分有限 ,而进行药用植物EST研究的国家相对较多 ,涉及的植物也相对集中 。

The Currents Status of the Plant Genome and EST Research in Medicinal Plants

The plant genome and EST research of over 2300 medicinal plants have been surveyed and classified based in the GenBank database.These plants are listed in following books: Modern Chinese Materia Medica, Chinese Pharmacopeia year 2000 edition Part I, Modern Research on Chinese Medicinal Herbs etc...Up to the end of September 2003,66% and 77% within the screened medicinal plants of those plants are failed to find DNA sequence and protein sequence registration in the GenBenk database respectively.Exept some of medicinal plants belonging to crop the results show that very limited medicinal plants are screened with dbGSS Id..About 13 species of medicinal plants with dbEST Id are available in the database.The perspective in this field is also discussed.;