Differential effects of chronic clorgyline and amfonelic acid on desensitization of striatal dopamine receptors |
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Authors: | E Meller K Bohmaker A J Friedhoff |
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Affiliation: | Millhauser Laboratories, Department of Psychiatry New York University School of Medicine 550 First Avenue, New York, N.Y. 10016, USA |
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Abstract: | Chronic treatment of rats with the MAOI clorgyline significantly reduced the density (Bmax) of cortical beta-adrenergic receptors but did not alter either the Bmax or dissociation constant (Kd) of 3H-spiperone binding to striatal DA receptors. Clorgyline co-treatment also did not significantly affect either behavioral supersensitivity to apomorphine or the increase in 3H-spiperone binding induced by chronic haloperidol. In contrast, repeated treatment with the DA uptake inhibitor amfonelic acid elicited behavioral subsensitivity and reduced striatal 3H-spiperone binding. Furthermore, amfonelic acid co-treatment prevented haloperidol-induced behavioral and receptor binding changes. The possible relevance of these findings in relation to drug choice in clinical trials of receptor sensitivity modification are discussed. |
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