Effect of intracerebral implantation of the embryonicLocus Coeruleus on the conditioned reflex avoidance reaction in rats with experimental atrophy of the frontotemporal brain cortex |
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| Authors: | D A Bevzyuk T M Vorob’yova O G Berchenko |
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| Institution: | (1) Ukrainian Institute of Clinical and Experimental Neurology and Psychiatry, Ministry of Public Health of Ukraine, Khar’kov, Ukraine |
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| Abstract: | We studied the effect of intracerebral grafting of the embryoniclocus coeruleus from donor rats on the conditioned reflex emotional avoidance reaction (EAR) and contents of adrenaline and noradrenaline
in the brain structures and body tissues of recipient rats. Group 1 of the animals consisted of intact rats, group 2 included
rats with electrolytic impairment and subsequent atrophy of the frontotemporal brain cortex regions, while in group 3 the
rats with impaired cortex were subjected to parallel transplantation of the embryoniclocus coeruleus into the injured region. Group-3 animals manifested a considerable level of recovery of the conditioned reflex behavioral
stereotype disturbed after the cortical injury. Biochemical analysis showed that transplantation of the embryoniclocus coeruleus exerts a rehabilitative/regulating influence on the functioning of the catecholaminergic systems in the group-3 rats. |
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| Keywords: | neurotransplantation conditioned reflex avoidance reaction locus coeruleus frontotemporal cortex noradrenaline |
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