Chromosome breakage and rejoining of sister chromatids in Bloom's syndrome |
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Authors: | Evelyn Meyer Kuhn Eeva Therman |
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Institution: | (1) Department of Medical Genetics, University of Wisconsin, 53706 Madison, Wisconsin, USA |
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Abstract: | The occurrence of chromosome breaks and reunion of sister chromatids in lymphocytes of two patients with Bloom's syndrome has been compared with those found in X-rayed and control cells. The distribution of breaks in BS is non-random both between and within chromosomes, the centric regions of certain chromosomes being preferentially involved. The following working hypotheses are put forward: When chromosome breaks in human lymphocytes occur in G0— G1, practically no sister chromatid reunion (SCR) takes place, whereas ends created by an S—G2 break show a considerable tendency to SCR. We propose further that chromosome aberrations in BS mainly result from breaks in S—G2, including possible U-type rejoining of sister chromatid exchanges. Fragments extra to an intact chromosome complement result from a chromatid break or an asymmetrical chromatid translocation in a previous mitosis. |
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