Discovery of novel antitubercular 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues |
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| Authors: | Ahsan Mohamed Jawed Samy Jeyabalan Govinda Soni Savita Jain Naresh Kumar Lalit Sharma Lalit K Yadav Hemant Saini Lokesh Kalyansing Rajput Gopal Devenda Narendra S Prasad Ravindra Jain Chandra Bhushan |
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| Institution: | New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan 301 030, India. jawedpharma@gmail.com |
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| Abstract: | In the present investigation, a series of 3a,4-dihydro-3H-indeno1,2-c]pyrazole-2-carboxamide/carbothioamide analogues were synthesized and were evaluated for antitubercular activity by two fold serial dilution technique. All the newly synthesized compounds showed low to high inhibitory activities against Mycobacterium tuberculosis H(37)Rv and INH resistant M. tuberculosis. The compound 3-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno1,2-c]pyrazole-2-carbothioamide (4o) was found to be the most promising compound active against M. tuberculosis H(37)Rv and isoniazid resistant M. tuberculosis with minimum inhibitory concentration 3.12 μM and 6.25 μM, respectively. |
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| Keywords: | Pyrazolines Antitubercular agents |
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