Polymerase chain reaction detection of two novel human N-acetylgalactosamine-6-sulfate sulfatase gene polymorphisms by single-strand conformation polymorphism analysis or by StyI and StuI cleavages |
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| Authors: | Shunji Tomatsu Seiji Fukuda Atsushi Uchiyama Toshinori Hori Yoshinori Nakashima Kazuko Sukegawa Naomi Kondo Yasuyuki Suzuki Nobuyuki Shimozawa Tadao Orii |
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| Institution: | (1) Molecular Genetics Department, IRO Cancer Research Institute, Hospital Duran i Reynals, Autovia de Castelldefels km 2.7, Hospitalet de Llobregat, E-08907 Barcelona, Spain |
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| Abstract: | A novel polymorphism (6376 G/T) in intron 7 (I7) of the human PROC gene has been identified by direct DNA sequencing. Restriction analysis with the use of mutagenic primers indicate that the allele frequencies are 0.17 (allele T) and 0.83 (allele G), with a calculated heterozygosity of 28%. |
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