New alkaloids from Strychnos icaja |
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| Authors: | N.G. Bisset Afaf A. Khalil |
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| Affiliation: | Pharmacognosy Research Laboratories, Department of Pharmacy, Chelsea College, University of London, Manresa Road, London SW3 6LX U.K. |
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| Abstract: | The alkaloids of Strychnos icaja (Loganiaceae) have been studied. An extract from Zaire leaf material yielded nine alkaloids, comprising novacine, the new base 21,22-α-epoxy-4,14-dihydroxy-3-methoxy-N-methyl-sec.-pseudostrychnine, and seven others of known structure previously obtained from the plant. Cameroun leaf material gave five alkaloids, of which one, 21,22-α-epoxy-3,4-dimethoxy-N-methyl-sec.-pseudostrychnine, is new. Fruits from Gabon afforded eight alkaloids; two of them are new and are formulated as 21,22-α-epoxy-4-methoxy-N-methyl-sec.-pseudostrychnine and the corresponding 14-hydroxy derivative. |
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| Keywords: | Loganiaceae indole alkaloids 4-methoxy-substituted indole alkaloids 3,4-dimethoxy-substituted indole alkaloids. |
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