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A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening
Authors:Rosa van den Berg  Sander Kooijman  Raymond Noordam  Ashna Ramkisoensing  Gustavo Abreu-Vieira  Lauren L. Tambyrajah  Wieneke Dijk  Philip Ruppert  Isabel M. Mol  Barbara Kramar  Rosanna Caputo  Laura Sardón Puig  Evelien M. de Ruiter  Jan Kroon  Menno Hoekstra  Ronald J. van der Sluis  Onno C. Meijer  Ko Willems van Dijk  Patrick C.N. Rensen
Affiliation:1. Department of Medicine, Division of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands;2. Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands;3. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK;4. Department of Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands;5. Department of Molecular Cell Biology, Division of Neurophysiology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands;6. Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6708 WE Wageningen, the Netherlands;7. Department of Neuroscience and Pharmacology, Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark;8. Department of Biopharmaceutics, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, the Netherlands;9. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, the Netherlands
Abstract:
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  • Keywords:circadian rhythm  diurnal rhythm  brown adipose tissue  triglycerides  fatty acids  lipoprotein lipase  angiopoietin-like 4  postprandial lipid response  Corresponding author
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