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The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation
Authors:Wensheng Zhang  Constantinos Chronis  Xi Chen  Heyao Zhang  Rapolas Spalinskas  Mercedes Pardo  Liangliang Chen  Guangming Wu  Zhexin Zhu  Yong Yu  Lu Yu  Jyoti Choudhary  Jennifer Nichols  Mana M Parast  Boris Greber  Pelin Sahlén  Kathrin Plath
Institution:1. Cam-Su Genomic Resource Center, Soochow University, Suzhou 215123, China;2. Wellcome Sanger Institute, Hinxton CB10 1SA, UK;3. Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;4. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA;5. Bioinformatics Program, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA;6. Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA;7. Science for Life Laboratory, Division of Gene Technology, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden;8. The Institute of Cancer Research, Chester Beatty Laboratories, London, UK;9. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany;10. Wellcome Trust – Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK;11. Department of Pathology, University of California, San Diego, La Jolla, CA, USA;12. Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA
Abstract:
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  • Keywords:pluripotency  self-renewal  cell fate decision  enhancers  differentiation  BAF complex  PRC2 complex  embryonic stem cells  histone modification
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