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Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
Authors:Yu Kitadate  David J Jörg  Moe Tokue  Ayumi Maruyama  Rie Ichikawa  Soken Tsuchiya  Eri Segi-Nishida  Toshinori Nakagawa  Aya Uchida  Chiharu Kimura-Yoshida  Seiya Mizuno  Fumihiro Sugiyama  Takuya Azami  Masatsugu Ema  Chiyo Noda  Satoru Kobayashi  Isao Matsuo  Yoshiakira Kanai  Shosei Yoshida
Institution:1. Division of Germ Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan;2. Department of Basic Biology, School of Life Science, Graduate University for Advanced Studies (Sokendai), 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan;3. The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK;4. Cavendish Laboratory, Department of Physics, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE, UK;5. Department of Pharmaceutical Biochemistry, Kumamoto University Graduate School of Pharmaceutical Sciences, Oe-Honmachi, Kumamoto 862-0973, Japan;6. AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan;7. Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan;8. Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan;9. Department of Molecular Embryology, Research Institute, Osaka Women’s and Children’s Hospital, Osaka Prefectural Hospital Organization 840, Murodo-cho, Izumi, Osaka, 594-1101, Japan;10. Laboratory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan;11. Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga 520-2192, Japan;12. Division of Environmental Photobiology, National Institute for Basic Biology, Okazaki 444-8585, Japan;13. Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan;14. Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, Immunology Frontier Research Center, World Premier International Research Center (WPI), Osaka University, Osaka 565-0871, Japan;15. Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan;16. Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK
Abstract:
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  • Keywords:stem cells  spermatogenesis  density homeostasis  open niche  biophysical modeling  mitogen competition  fibroblast growth factors
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