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Phenotypic Plasticity: Driver of Cancer Initiation,Progression, and Therapy Resistance
Authors:Piyush B. Gupta  Ievgenia Pastushenko  Adam Skibinski  Cedric Blanpain  Charlotte Kuperwasser
Affiliation:1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA;2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;3. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA;4. Harvard Stem Cell Institute, Cambridge, MA 02138, USA;5. Université Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium;6. Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA;7. Raymond and Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA;8. Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington St., Boston, MA 02111, USA;9. WELBIO, Université Libre de Bruxelles, Brussels 1070, Belgium
Abstract:
Keywords:plasticity  cancer  epithelial to mesenchymal transition  therapy resistance
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