Metabolism of cholesterol by callus culture of Holarrhena antidysenterica |
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Authors: | MR Heble S Narayanaswamy MS Chadha |
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Institution: | Bio-Organic Division, Bhabha Atomic Research Centre, Bombay 400 085, India |
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Abstract: | A chemically defined medium was established for the growth of tissue cultures of Holarrhena antidysenterica. Administration of cholesterol-4-14C] to 10-day-old callus yielded radioactive 24-methylenecholesterol, 28-isofucosterol, sitosterol, stigmasterol, and conessine, thereby indicating that the conversion of cholesterol into sitosterol is mediated through 24-methylenecholesterol and 28-isofucosterol in this system. |
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Keywords: | callus culture cholesterol metabolism |
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