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A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome
Authors:Elena G. Bochukova  Katherine Lawler  Sophie Croizier  Julia M. Keogh  Nisha Patel  Garth Strohbehn  Kitty K. Lo  Jack Humphrey  Anita Hokken-Koelega  Layla Damen  Stephany Donze  Sebastien G. Bouret  Vincent Plagnol  I. Sadaf Farooqi
Affiliation:1. University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK;2. The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK;3. The Saban Research Institute, Developmental Neuroscience Program, and Diabetes and Obesity Program, Children’s Hospital Los Angeles, Center for Endocrinology, Diabetes and Metabolism, University of Southern California, Los Angeles, CA 90027, USA;4. Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France;5. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland;6. University College London Genetics Institute (UGI), Department of Genetics, Environment and Evolution, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK;7. Department of Neurodegenerative Disease, University College London Institute of Neurology, London, WC1N 3BG, UK;8. Erasmus University Medical Center, Rotterdam, the Netherlands;9. Dutch Growth Research Foundation, Rotterdam, the Netherlands
Abstract:
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  • Keywords:hypothalamus  Prader-Willi syndrome  BDNF  Agrp  obesity  SNORD116
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