Continuous two step bioconversion of 4-oxoiso-phorone (OIP) to 4-hydroxy-2,2,6-trimethylcyclo-hexanone (4-HTMCH) by thermophilic bacteria |
| |
| Authors: | Kunio Nishii Koji Sode Isao Karube |
| |
| Institution: | (1) Research Lab. Pharmaceuticals Group Nippon Kayaku Co., Ltd., 31-12 Shimo 3-chome Kitaku, 115 Tokyo, Japan;(2) Department of Biotechnology Faculty of Technology, Tokyo University of Agriculture & Technology, 2-24-16 Naka-cho Koganei, 184 Tokyo, Japan;(3) Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba Meguroku, 153 Tokyo, Japan |
| |
| Abstract: | Summary The continuous two step conversion of 4-oxoisophorone(OIP) to 4-hydroxy-2,2,6-trimethylcyclohexanone(4-HTMCH) via dihydrooxoisophorone(DOIP) was carried out using two types of thermophilic growing cells, Thermomonospora curvata and Bacillus stearothermophilus, in sequential connected continuous stirred tank reactor(CSTR) and hollow fiber reactor system. For more than 80 hours operation, 46% of OIP was converted to 4-HTMCH with productivity of 179 mg/h/l. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
