Microarchitecture and Nanomechanical Properties of Trabecular Bone After Strontium Administration in Osteoporotic Goats |
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| Authors: | Zhaoyang Li Songlin Peng Haobo Pan Bin Tang Raymond W M Lam William W Lu |
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| Institution: | (1) Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China;(2) Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China;(3) Department of Orthopaedics and Traumatology, The University of Hong Kong, Room 907, Lab Block, 21 Sassoon Road, Hong Kong, China; |
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| Abstract: | Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98%
of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture
and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according
to the treatment regimen: control, calcium alone (Ca), calcium and Sr at 24 mg/kg (Ca + 24Sr), and calcium and Sr at 40 mg/kg
(Ca + 40Sr). The effects of Sr administration on bone microarchitecture and nanomechanical properties of trabecular bones
were analyzed with micro-CT and nanoindentation test, respectively. Serum Sr levels increased six- and tenfold in the Ca + 24Sr
and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr administration
significantly increased trabecular bone volume fraction, trabecular thickness, and double-labeled new bone area. Sr administration,
however, did not significantly change the nanomechanical properties of trabecular bone (elastic modulus and hardness). The
data suggested that Sr administration increased trabecular bone volume and improved the microarchitecture while maintaining
the intrinsic tissue properties in the osteoporotic goat model. |
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