Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages |
| |
| Authors: | Joel A Dave Nico C Gey van Pittius Albert D Beyers Mario RW Ehlers and Gordon D Brown |
| |
| Institution: | (1) Department of Medical Biochemistry, University of Cape Town Medical School, Observatory, Cape Town, 7925, South Africa;(2) US/MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, Bellville, 7505, South Africa;(3) Pacific Biometrics, Inc, 220 West Harrison Street, Seattle, WA 98119, USA;(4) Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom |
| |
| Abstract: | Background Exported proteases are commonly associated with virulence in bacterial pathogens, yet there is a paucity of information regarding their role in Mycobacterium tuberculosis. There are five genes (mycP1-5) present within the genome of Mycobacterium tuberculosis H37Rv that encode a family of secreted, subtilisin-like serine proteases (the mycosins). The gene mycP1 (encoding mycosin-1) was found to be situated 3700 bp (four ORF's) from the RD1 deletion region in the genome of the attenuated vaccine strain M. bovis BCG (bacille de Calmette et Guérin) and was selected for further analyses due to the absence of expression in this organism. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
