Regulation of prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid |
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| Authors: | S Murad A Sivarajah S R Pinnell |
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| Institution: | 1. Division of Dermatology Department of Medicine Duke University Medical Center Durham, North Carolina 27710 USA;2. the Howard Hughes Medical Institute Laboratories at Duke University Medical Center Duke University Medical Center Durham, North Carolina 27710 USA |
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| Abstract: | Studies with confluent human skin fibroblasts maintained in 0.5% serum supplemented medium have given new insight into the regulatory influences of ascorbate. These include a reduction of prolyl hydroxylase activity, a stimulation of lysyl hydroxylase activity, and an acceleration of collagen production. The lack of parallel between prolyl hydroxylase activity and collagen production indicates that the rate of collagen synthesis is not controlled by the level of prolyl hydroxylase. |
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