Functional Mapping of the Human Visual Cortex with Intravoxel Incoherent Motion MRI |
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| Authors: | Christian Federau Kieran O’Brien Adrien Birbaumer Reto Meuli Patric Hagmann Philippe Maeder |
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| Institution: | 1Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland;2Center for Biomedical Imaging (CIBM), University of Geneva, Geneva, Switzerland;University of Michigan, UNITED STATES |
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| Abstract: | Functional imaging with intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) is demonstrated. Images were acquired at 3 Tesla using a standard Stejskal-Tanner diffusion-weighted echo-planar imaging sequence with multiple b-values. Cerebro-spinal fluid signal, which is highly incoherent, was suppressed with an inversion recovery preparation pulse. IVIM microvascular perfusion parameters were calculated according to a two-compartment (vascular and non-vascular) diffusion model. The results obtained in 8 healthy human volunteers during visual stimulation are presented. The IVIM blood flow related parameter fD* increased 170% during stimulation in the visual cortex, and 70% in the underlying white matter. |
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