Antibacterial Activity and Inhibition of Adherence of Streptococcus mutans by Propolis Electrospun Fibers |
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| Authors: | Chawalinee Asawahame Krit Sutjarittangtham Sukum Eitssayeam Yingmanee Tragoolpua Busaban Sirithunyalug Jakkapan Sirithunyalug |
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| Affiliation: | Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Suthep Rd., Muang district Chiang Mai, 50200 Thailand ;Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200 Thailand ;Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200 Thailand |
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| Abstract: | Mouth-dissolving fibers with antibacterial activity for the oral cavity were prepared by an electrospinning technique. Propolis extract was used as an active ingredient and polyvinylpyrrolidone (PVP) K90 as the polymer matrix. The morphology and diameter of the fibers were characterized by scanning electron microscopy. Antibacterial activity against Streptococcus mutans and the inhibition of S. mutans adhesion on a smooth glass surface during the biofilm formation were tested. Propolis, 5% (w/v), was combined with a PVP K90 solution, 8% (w/v), with or without Tween 80 including flavor additives and electrospun with an applied voltage of 15 kV. Uniform and smooth fibers of propolis-PVP K90 were obtained. The results showed that electrospun fibers with propolis extract can dissolve and release the propolis in water. Propolis-PVP electrospun fibers showed better antibacterial activity by reduction of bacteria adhesion on a smooth glass surface when compared to some commercial mouthwash products. These results indicated the potential of electrospun fibers to be used as mouth-dissolving fibers for effective antibacterial activity in the oral cavity.KEY WORDS: antibacterial activity, electrospun fibers, inhibition of adherence, propolis, Streptococcus mutans |
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