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Human plasma DSIP decreases at the initiation of sleep at different circadian times |
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| Authors: | Erich Seifritz Matthias J Müller Guido A Schnenberger Lorenz Trachsel Ulrich Hemmeter Martin Hatzinger Andreas Ernst Polly Moore Edith Holsboer-Trachsler |
| Institution: | a Depression Research Unit, Psychiatric University Hospital, Wilhelm Kleinstr. 27, 4025, Basel, Switzerland b Psychiatry Service, San Diego Veterans Affairs Medical Center, 9500 Gilman Dr., La Jolla, CA 92093-0603, USA c Department of Psychiatry, University of California at San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0603, USA d MCM AG, Medizinisches Centrum Mariastein, Metzerlenstr 1, 4115, Mariastein, Switzerland e Max Planck Institute of Psychiatry, Clinical Institute, Kraepelinstr. 2-10, 80804, Munich, Germany |
| Abstract: | Nocturnal plasma delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) was determined serially in seven healthy male subjects. Time courses during nocturnal sleep (2300-0800 h), nocturnal sleep deprivation (2300-0500 h), and morning recovery sleep (0500–0800 h) after sleep deprivation were compared. A significant decrease in plasma DSIP-LI was found at the transition from wakefulness to sleep in both evening sleep (2300 h) and morning recovery sleep (0500 h). Time courses were accompanied by physiological changes in sleep electroencephalographic slow-wave activity, and in plasma concentrations of cortisol and human growth hormone. No sleep stage specificity was found. It is concluded that DSIP is influenced by the initiation of sleep. |
| Keywords: | Delta sleep-inducing peptide (DSIP) Cortisol Growth hormone Sleep electroencephalographic slow-wave activity EEG Sleep homeostasis Sleep onset Circadian rhythm Human |
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