| ABCA1的胞内运输及功能研究新进展 |
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| 引用本文： | 唐艳艳,陈五军,路 倩,唐朝克. ABCA1的胞内运输及功能研究新进展[J]. 生物化学与生物物理进展, 2013, 40(6): 510-519 |
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| 作者姓名： | 唐艳艳 陈五军 路 倩 唐朝克 |
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| 作者单位： | 南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，生命科学研究中心，衡阳 421001,南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，生命科学研究中心，衡阳 421001；南华大学药物药理研究所，衡阳 421001,南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，生命科学研究中心，衡阳 421001,南华大学心血管疾病研究所，动脉硬化学湖南省重点实验室，生命科学研究中心，衡阳 421001 |
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| 基金项目： | 国家自然科学基金资助项目(81170278, 81070220) |
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| 摘 要： | 三磷酸腺苷结合盒转运体A1(ABCA1)具有介导细胞内脂质流出，维持细胞脂质稳态的功能．新生的ABCA1必须经过胞内运输和各种化学修饰等过程，最终成为具有功能的成熟转运体，才能行使其转运脂质的功能，因此，ABCA1在胞内的运输过程和正确质膜定位对其介导胆固醇流出的功能至关重要．目前ABCA1相关研究主要集中于脂质转运方面，并提出各种胆固醇流出机制的模型，如通道转运模型、蘑菇状突起模型和胞吞-胞吐转运模型等．最近研究显示，ABCA1还具有调节质膜脂筏结构、参与免疫和炎症调节等新功能．本文主要针对ABCA1的胞内运输过程以及各种功能做一综述，以期为动脉粥样硬化相关疾病提供新的治疗靶点和途径．
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| 关 键 词： | 三磷酸腺苷结合盒转运体A1(ABCA1)，胞内运输，胆固醇流出，免疫，炎症 |
| 收稿时间： | 2012-08-21 |
| 修稿时间： | 2012-11-02 |
Research Advances of Intracellular Transport and Function of ABCA1 |
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| TANG Yan-Yan,CHEN Wu-Jun,LU Qian and TANG Chao-Ke. Research Advances of Intracellular Transport and Function of ABCA1[J]. Progress In Biochemistry and Biophysics, 2013, 40(6): 510-519 |
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| Authors: | TANG Yan-Yan CHEN Wu-Jun LU Qian TANG Chao-Ke |
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| Affiliation: | Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center University of South China, Hengyang 421001, China,Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center University of South China, Hengyang 421001, China; Insitute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China,Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center University of South China, Hengyang 421001, China and Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center University of South China, Hengyang 421001, China |
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| Abstract: | ATP-binding cassette transporter 1 (ABCA1) mediated lipid efflux and evolved to maintain cholesterol homeostasis. Newborn ABCA1 should through intracellular transport and chemical modification, ultimately being a mature functional transporter with its function of lipid transport. The intracellular transport and correct localization of ABCA1 plays an important role in its function. ABCA1 researches focused on the lipid transport, and proposed the model of the various cholesterol efflux mechanisms, such as channel transport model, mushroom-like protuberances model and retroendocytosis model. Recent studies have shown, ABCA1 can regulate the plasma membrane lipid rafts, and involve in immune and inflammatory regulation. This review focuses on the current views on intracellular transport and various functions of ABCA1, in order to provide the new therapeutic targets for atherosclerosis-related diseases. |
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| Keywords: | ATP-binding cassette transporters A1(ABCA1) intracellular transport cholesterol efflux immune inflammatory |
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