CELL PROLIFERATION IN THE CASTRATE MOUSE SEMINAL VESICLE IN RESPONSE TO TESTOSTERONE PROPIONATE |
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| Authors: | David Appleton Adrian R Morley Nicholas A Wright |
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| Institution: | Departments of Medical Statistics and Pathology, University of Newcastle upon Tyne |
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| Abstract: | The cell proliferation kinetics following induced DNA synthesis in the mouse seminal vesicle were measured after treatment with testosterone propionate. Fraction labelled mitosis curves at 24, 48 and 72 hr after injection gave t 2 values of 1·5, 2·0 and 1·8 hr respectively, and t s values of 10·5, 8·0 and 8·0 hr. T c measured 48 hr after stimulation was 17·5 hr. Growth fraction rose from 0·14 at 24 hr to 0·64 at 48 hr, and fell to 0·32 by 72 hr. A simple model is proposed in which the rise and fall of mitotic index and labelled index is determined by the 'cell distribution ratio'. |
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