Inhibition of Bovine Carbonic Anhydrase by New Sulfonamide Compounds |
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Authors: | O Arslan |
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Institution: | (1) Department of Chemistry, Balikesir University Faculty of Science and Arts, Balikesir, Turkey |
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Abstract: | Inhibitory effects of three new derivatives of 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide on bovine carbonic anhydrase have been investigated. The new compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide, 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide, and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide. The new compounds inhibit the esterase activity of carbonic anhydrase noncompetitively and have inhibition constants and I
50 values very similar to those for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, the latter being clinically used in the treatment of glaucoma. |
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Keywords: | inhibition bovine carbonic anhydrase sulfonamides |
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