GP73 与消化系统疾病的研究进展

高尔基体是一个非常重要的细胞器，最近研究表明，它除了蛋白加工外，还能参与细胞分化、细胞间信号传导和细胞凋亡， 其功能障碍也许和疾病的发生、发展有着某种联系。随着蛋白组学技术的发展，使得筛选新的肿瘤标志物成为可能，其中高尔基 体蛋白73（GP73）被认为是最值得期待的血清标志物之一，尤其是早期肝癌的血清标志物。本文对近年来有关GP73 结构、表达分 布以与及消化系统疾病的研究进展进行综述。

Research Progress of the Relationship Between GP73 and Digestive SystemDisease

The Golgi body is a very important organelle. Recent studies have shown that it not only can process protein, but also participate in cell differentiation, signal transduction and apoptosis, its dysfunction may be involved in the onset and development of diseases. The development of proteomics technology makes screening new tumor markers become possible, Golgi protein 73 (GP73) is considered to be one of the most anticipated, especially serum markers of early liver cancer. In this paper, the recent researches which have related to GP73 structure, expression with distribution and digestive systemdisease are reviewed briefly .