Development of E.coli virus T1: the pattern of gene expression. |
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Authors: | Erwin Friedrich Wagner Helmut Ponta and Manfred Schweiger |
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Institution: | (1) Max-Planck-Institut für Molekulare Genetik, Ihnestr. 63-73, D-1000 Berlin 33;(2) Present address: Institut für Biochemie, Universit?t Innsbruck, Austria |
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Abstract: | Summary T1 infected bacteria exhibit a distinct pattern of gene expression. The control of this expression is accessible to biochemical
analysis. T1 induces the synthesis of 31 proteins inE. coli. The virion contains 15 proteins. By means of T1 amber mutants, 10 gene products have been assigned to specific T1 genes.
Three classes of T1 proteins are defined by the kinetics of their syntheses: early, early-late and late proteins. The regulation
of protein synthesis involves at least three mechanisms: for cessation of host gene expression, for discontinuation of the
early class during the late phase and for induction of the late T1 proteins. The positive control of late gene expression
is not coupled to replication. The host RNA-polymerase transcribes the viral genome throughout the infectious cycle. No virus
coded RNA-polymerase is induced. |
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Keywords: | |
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