Identity of dihydrodiol dehydrogenase and 3 alpha-hydroxysteroid dehydrogenase in rat but not in rabbit liver cytosol |
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| Authors: | Walter Wörner Franz Oesch |
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| Affiliation: | Institut für Toxikologie, Obere Zahlbacher Strasse 67, D-6500 Mainz, FRG |
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| Abstract: | Dihydrodiol dehydrogenase and 3 alpha-hydroxysteroid dehydrogenase activity in rat and rabbit liver cytosol have been analyzed by isoelectric focussing and subsequent activity staining. Identity of the two enzymes in rat liver cytosol is demonstrated. At least 4 main enzyme forms possessing dihydrodiol dehydrogenase activity can be detected in rabbit liver cytosol. However, in this species, only one of these forms has measurable activity towards 3 alpha-hydroxysteroids. |
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| Keywords: | 3α-Hydroxysteroid dehydrogenase Aldo/keto reductase Activity staining |
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