SCHIP: statistics for chromosome interphase positioning based on interchange data |
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Authors: | Vives Sergi Loucas Bradford Vazquez Mariel Brenner David J Sachs Rainer K Hlatky Lynn Cornforth Michael Arsuaga Javier |
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Institution: | Departmento de Estadistica, Universidad de Barcelona Barcelona 08028, Spain. |
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Abstract: | MOTIVATION: The position of chromosomes in the interphase nucleus is believed to be associated with a number of biological processes. Here, we present a web-based application that helps analyze the relative position of chromosomes during interphase in human cells, based on observed radiogenic chromosome aberrations. The inputs of the program are a table of yields of pairwise chromosome interchanges and a proposed chromosome geometric cluster. Each can either be uploaded or selected from provided datasets. The main outputs are P-values for the proposed chromosome clusters. SCHIP is designed to be used by a number of scientific communities interested in nuclear architecture, including cancer and cell biologists, radiation biologists and mathematical/computational biologists. |
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