A Comparison of the Biological Characteristics of EV71 C4 Subtypes from Different Epidemic Strains |
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| Authors: | Li-chun WANG Song-qing TANG Yan-mei LI Hong-lin ZHAO Cheng-hong DONG Ping-fang CUI Shao-hui MA Yun LIAO Long-ding LIU Qi-han LI |
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| Affiliation: | Li-chun WANG,Song-qing TANG,Yan-mei LI,Hong-lin ZHAO,Cheng-hong DONG,Ping-fang CUI,Shao-hui MA,Yun LIAO,Long-ding LIU , Qi-han LI (Institute of Medical Biology,Chinese Academy of Medical Sciences,Peking Union Medical College,Kunming 650118,China) |
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| Abstract: | The comparative analysis of the biological characterization and the genetic background study of EV71 circulating strains is commonly recognized as basic work necessary for development of an effective EV71 vaccine. In this study, we sequenced five EV71 circulating strains, isolated from Fuyang, Hefei, Kunming and Shenzhen city of China and named them FY-23, FY-22, H44, K9 and S1 respectively. The sequence alignment demonstrated their genotypes be C4. The genetic distance of the VP1 gene from these isolates s... |
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| Keywords: | Enterovirus 71 (EV71) Subtype C4 Epidemic strain Hand-foot and mouth disease (HFMD) |
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