Effects of Milnacipran in Animal Models of Anxiety and Memory |
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Authors: | Vânia K M Moojen Márcio Rodrigo Martins Adalisa Reinke Gustavo Feier Fabiano R Agostinho Édson M Cechin João Quevedo |
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Institution: | (1) Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil;(2) Grupo de Neurosciências, Faculdade de Medicina, Universidade de Passo Fundo, 99100-000 Passo Fundo, RS, Brazil |
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Abstract: | Serotonin (5-HT) and noradrenaline (NA) are involved in both pathogenesis and recovery from depression and anxiety. We examined the effects of acute and chronic treatment with milnacipran, a serotonin/noradrenaline reuptake inhibitors (SNRIs) antidepressant, on anxiety and memory retention in rats. Male Wistar rats received acute or chronic administration of milnacipran (12.5, 25 or 50 mg/kg) or saline (control group). The animals were separately submitted to elevated plus-maze, inhibitory avoidance and open-field tasks 1 h after injection, in the acute group, or 23 h after last injection, in the chronic group. Our results showed an anxiolytic-like effect after chronic administration of milnacipran at doses of 25 and 50 mg/kg. The treatment does not interfere in memory retention and habituation to a novel environment at any doses studied. These findings support that milnacipran, an established SNRIs antidepressant, can also be useful in the treatment of anxiety disorders. |
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Keywords: | Milnacipran SNRIs Anxiety Memory Rat |
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