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Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes |
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| Authors: | Su Dai-Shi Lim John L Markowitz M Kristine Wan Bang-Lin Murphy Kathy L Reiss Duane R Harrell C Meacham O'Malley Stacy S Ransom Rick W Chang Raymond S L Pettibone Douglas J Tang Cuyue Prueksaritanont Thomayant Freidinger Roger M Bock Mark G |
| Institution: | Department of Medicinal Chemistry, West Point, PA 19486, USA. daishi_su@merck.com |
| Abstract: | Selective bradykinin (BK) B(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B(1) receptor antagonists. |
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