Heparin interacts with a selenoprotein in human plasma |
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| Authors: | B Akesson B M?rtensson |
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| Affiliation: | Department of Clinical Chemistry, University Hospital, University of Lund, Sweden. |
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| Abstract: | The major selenium-containing peak at gel filtration of human serum on Sephadex G-150 had a Kav of 0.19, but at chromatography of heparinized plasma this peak had a Kav of 0.01, indicating an interaction between heparin and a major selenium-containing protein. The addition of protamine abolished the effect of heparin. The heparin-interacting protein was not identical to glutathione peroxidase. The data explain some previous discrepancies on selenium distribution in plasma due to the use of different anticoagulants. |
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