Application of chemically induced dynamic nuclear polarization to the nitration of N-acetyltyrosine and to some reactions of peroxynitrite. |
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Authors: | A R Butler T J Rutherford D M Short J H Ridd |
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Affiliation: | Centre for Biomolecular Sciences, University of St Andrews, Fife, KY16 9ST, Scotland. arb3@st-andrews.ac.uk |
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Abstract: | By the observation of chemically induced dynamic nuclear polarization in (15)N NMR spectroscopy it has been shown that nitration of N-acetyltyrosine, even under acidic conditions, is largely a radical process. In the alkaline reaction of tyrosine with peroxynitrite the main products are nitrite and nitrate, both produced by a radical pathway, and tyrosine nitration is a minor reaction. It is suggested that tyrosine catalyzes the production of NO(*)(2) and HO(*) from peroxynitrite. |
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