Brain microvessel endothelin type A receptors are coupled to ceramide production |
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Authors: | Collado M Pilar Latorre Eduardo Fernández Inmaculada Aragonés M Dolores Catalán R Edgardo |
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Institution: | Departamento de Bioquímica y Biología Molecular I, Facultad de Químicas, Universidad Complutense de Madrid, E-28040, Madrid, Spain. |
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Abstract: | Treatment of brain microvessels with endothelin-1 evoked an early decrease in the sphingomyelin levels concomitantly with an increase in those of ceramides. These responses were time- and concentration-dependent. Evidence also shows that endothelin type A receptors are involved. This is the first report on the involvement of an agonist in the regulation of the ceramide signal transduction system on blood-brain barrier and shows a new pathway likely involved in the regulation of the cerebral microvascular functioning. |
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Keywords: | Endothelin 1 Ceramide Blood-brain barrier |
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