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Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains |
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| Authors: | WeiZhong Li Heng Zhang GeFei Wang Chi Zhang XiangXing Zeng Hui Liu XiaoXuan Chen YanXuan Xu KangSheng Li |
| Institution: | 1. Department of Microbiology and Immunology, Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou, 515041, China 2. Department of Veterinary Medicine, University of Maryland, College Park, MD, 20742, USA 3. Department of Ultrasonic, Central Hospital of Luoyang City, Luoyang, 471009, China |
| Abstract: | Non-structural protein 1 (NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication. The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently. In the present study, the NS1 protein from the A/Shantou/602/06(H3N2) virus (herein abbreviated as NS32) was found to interact with NS1 from A/Shantou/169/06(H1N1), A/Chicken/Guangdong/1/05(H5N1) and A/Quail/Hong Kong/G1/97(H9N2) (abbreviated as NS11, NS51 and NS92, respectively) viruses, although NS32 shares 17.4%?C20.9% sequence diversity with NS11, NS51 and NS92. This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/ strains may be a common event during co-infection. |
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