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Backbone chemical shift assignments of the acyl-acyl carrier protein intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum |
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| Authors: | Santosh Kumar Upadhyay Ashish Misra Namita Surolia Avadhesha Surolia Monica Sundd |
| Affiliation: | 1. National Institute of Immunology, Aruna Asaf Ali Marg, JNU Campus, New Delhi, 110067, India 2. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560 012, India 3. Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560 064, India |
| Abstract: | We report the backbone chemical shift assignments of the acyl-acyl carrier protein (ACP) intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum. The acyl-ACP intermediates butyryl (C4), -octanoyl (C8), -decanoyl (C10), -dodecanoyl (C12) and -tetradecanoyl (C14)-ACPs display marked changes in backbone HN, Cα and Cβ chemical shifts as a result of acyl chain insertion into the hydrophobic core. Chemical shift changes cast light on the mechanism of expansion of the acyl carrier protein core. |
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